I can't left click

I'm having a bit of trouble because it seems like my mouse left clicks aren't going through to the game except on rare occasions where my left click works, like, once. I'm not sure what's going on, I tried resetting controls to default but that didn't do anything.

It's really annoying because I can't ping and I also cant cast abilities without quick cast, and stuff like Taliyah's ult really doesn't work great with quick cast.

Can I get some help please?

Edit: I tried deleting my config folder, I went into a custom game and it was still bugged