Abilities that aren't autoattacks have no vaild targets?

Often during the first part of a game, sometimes continuing all game, I am unable to target enemy or sometimes even friendly champions with targeted (non-aoe or self cast) abilities (ie QWER) or summoner spells. No silences, stuns, or other actions blockers are present, it does not coincide with lag or major frame drops on anything more than a seemingly random basis, and I do not have smart cast on at any time. It does happen more often with Azir, but he tends to be buggy as hell no matter what. I have checked my control setup, and no issues with anything other than league. I cannot reliably play anything except champions like Nasus or Thresh (or most ADCs) at the moment, because this is affecting everything BUT autoattacks. Being under the impression that autoattacks are counted as an ability in the code, I honestly have no clue why this is.