Buttons Not Working [IN GAME]

So, in every game I have been playing recently my buttons won't work. My Q, W, E, R D, F, B, all the numbers and all the letters won't work. When this first happened, I rebinded my keys to things like , . / ; ' [ ] because these keys seem to be the only ones that work. In every other game, I try to rebind them to what they were before, q w e and r, but it doesn't even sense me pressing the keys. This ONLY happens in league. Anybody that could help me?