Beta Client Bug
After leaving the league of legends client minimized for an extended duration, upon returning to the client all actions taken are unresponsive (for example: clicking on any of the options such as, profile, play, quit, play again, collection, loot, store, etc., all result in inaction). After experiencing the issue I have to restart the client and the problem is resolved. It has happened several times, only after the client has been minimized or inactive for an extended period of time.