ShadowPlay and flickering

I'm not sure if anyone else has experienced this, but here are the steps to reproduce my issue:

1. Have ShadowPlay desktop recording enabled.
2. Have a hotkey set for ShadowPlay recording Push to Talk and set the record mode to Push to Talk. Ensure that ShadowPlay records microphone sound.
3. Activate the Push to Talk hotkey while in game. The game screen will flicker occasionally (usually happens every press, but may take a few presses for it to get started.

I have not observed this behavior in any other games I've tried. The game is in windowed mode at a resolution of 3750x1440. This occurs, however, regardless of whether I am using full screen, windowed, or borderless window.