My Keys Don't Work At All In-Game

My key's in-game don't respond to me pressing them unless i hold down the windows key and then use them. The keys that don't work for me include, Q, W, E, R, D, F, G, V, 1, 2, 3, 4, 5 ,6, 7, B, A-click, and P. I've tried re-binding them but I literally cant press them and have them respond individually in-game. If i spam abilities eventually one of them eventually goes off but that isn't very helpful. Can anyone help?