[GAMEPLAY] Number and letter keys don't respond

Sometimes when I get into a game the number and letter keys won't respond at all when I use them. Tab, escape, and enter work just fine in fact I can press enter and use the letter and number keys like normal to type a message. My keyboard works fine in every other thing I do. I've only been playing intermediate bots on summoner's rift so I don't know if it happens in other places but I'd guess it would. It happened a week ago on the 23rd of August where I played Katarina then the 25th with Scion then today with Jhin. I haven't noticed a cause or pattern it just seems to happen randomly for an entire game and then it works again if I start a new one. I tried rebinding my keys but it didn't respond when I typed a letter. I can click on my abilities and everything else and play that way no problems there.