Mac, HiDPI/Retina Cursor position bug

I use a Macbook Pro 15" with an external HiDPI display running 5160x2880 that I use when playing League. I run the game at 2560x1440, which displays correctly, but clicking the mouse in the bottom 1/3 of the screen results in the mouse jumping to the top 1/3 of the screen causing spells and movements to occur in the wrong direction. This is INCREDIBLY frustrating when trying to flash or cast an ability shot to land a final blow and it goes in the opposite direction or causes you to die and get flamed when you flash into an enemy.

I haven't been able to find a fix for this other than altering my playstyle and using champion-camera-follow more often. Switching the resolutions around sometimes seems to help.