This is a general Rune page combination guide for a wide range of use on all champions.
I will list every rune page that is viable for a very general champion and play style, and a few specialized rune pages.
First off my average Mid AP rune page is x9 Magic Pen Marks, x3 Ability Power Quintessence, x9 Ability power glyphs, x5 / x4 armor and Magic resist Seals, the seals should be defensive, but it depends on who you are against and what you prefer [You will have 26 Ability Power, 7.8 Magic Pen, 5 Armor 3 Magic resist].
Next is my average AD champion rune page, I use this for Assassins Top/Mid and ADC's and even most Junglers, this also works for Tanky Top lane AD champs, you get good early damage to farm and you just build Tanky, with 1-2 damage items. This rune page consists of x1 0.93% Critical chance Mark, x8 0.95 AD Marks, x9 Armor Seals, x9 Magic resist Glyphs, x3 Attack Speed Quintessence [You will have 0.93% Critical chance, 7.6 AD, 14% Attack Speed, 9 Armor, 12 Magic Resist].
Next is my AP Tanky attack speed rune page. I use this mostly for Sejuani jungle, Maokai Top, Kayle Top, those sort of champions. It consists of x9 1.7% attack speed Marks, x9 Armor Seals, x9 Magic Resist Glyphs, and x3 4.95 Ability Power Quintessence [You will have 15 Ability Power, 15% Attack Speed, 9 Armor, 12 Magic Resist].
Next is my Super Tanky / Support rune pages. These are extremely well for EARLY game Tankyness. They are as follows, x9 0.91 Armor Marks, x7 1 Armor Seals, x9 Magic Resist Glyphs, x3 Armor Quintessence [You will have 28 Armor and 14 Magic Resist].
Next is a specialized rune page I use occasionally with Gangplank specifically, These runes are PURE CRITICAL DAMAGE which gives you 46% increased Critical Damage, stacked with an early Infinity Edge and Last Whisper into more Critical chance items, you will have 296% Critical Damage. I alter between these runes and Critical chance with AD.
Next is my Specialized Tryndamere and Yasuo CRITICAL CHANCE Runes, These give a flat 20% Crit chance. With Tryndamere, these runes will out trade almost ANY Top lane as long as you play safe until your red bar is full, once it is full you will have 55% Critical chance with no items, RUSH an Infinity Edge on both Yasuo and Tryndamere.
Next is my Specialized runes for Shaco Jungle. These runes consist of x9 0.95 AD Marks, x9 Armor Seals, x9 Ability Power Glyphs, x3 Attack Speed Quintessence [You will have 8.5 AD, 14% Attack Speed, 11 Ability Power, 9 Armor].
Next will be my Specialized Draven runes, I do not always prefer these with Draven, but most of the time I do. These runes consist of x9 0.95 AD Marks, x9 0.43 AD Seals, x7 @LvL18 Scaling AD Glyphs x2 0.28% Critical Chance Glyphs, and x3 2.25 AD Quintessence [You will have 19 AD 5.1 AD @LvL18 and 0.56% Critical Chance which rounds up to 1% in-game (as far as I know)]. An alternate option for Draven is to have the following Runes, x9 1.7% Attack Speed Marks, x9 @LvL18 AD Seals, x7 @LvL18 AD Glyphs, x2 0.28% Critical Chance Glyphs, and x3 @LvL18 AD Quintessence [You will have 15% Attack Speed, 28 AD @LvL18, and 0.56% Critical chance, or 1% in-game].
Last but not least, I have recently been messing around with an ALL OFFENSIVE ADC/AD Top lane rune page that is decent if you KNOW you won't be taking a lot of damage in trades. This rune page consists of x5 0.95 AD Marks, x4 0.93% Critical Chance Marks, x8 0.42% Critical Chance Seals, x1 0.43 AD Seal, x9 0.28% Critical Chance Glyphs and x3 4.5% Attack Speed Quintessence [You will have 5.2 AD, 14% Attack Speed, and 9.6% Critical chance, which rounds up to 10% Critical chance in-game.
That is all for now, I really hope that this helps anyone that ever needs some assistance, as I know league is very difficult and doesn't really come with any Rune/Masteries Guides or Tips. Thanks! Feel free to leave me your feedback!!
(PLEASE NOTE THAT ALL DEFENSIVE RUNES IN ALL PAGES CAN BE REPLACES WITH RUNES THAT SCALE AT LEVEL 18, AS IN MOST CASES THEY ARE BETTER, AND THEY BECOME BETTER AT LEVEL 9)
P.S. Movement Speed Quintessence are VERY useful in several situations, if you feel you don't need the damage or defensive stats from your current Quintessences, you can replace them with x3 Movement Speed Quintessence for 4.5% Movement Speed Bonus which can make a huge difference on champions that are easily kited or have low mobility. With rank 1 boots you are ALMOST as quick as someone with tier two boots, especially if you have ANY movement speed items (not counting boots).