Eh, I’m not worried.
The Watchers are not back. They made a decent crack in the True Ice at the bottom of the Howling Abyss. The Frostguard are handling it well, sending inspection teams to all True Ice sites, and no doubt will ask Lissandra to repair any damaged ones.
Targon is doing just fine. Their job is fighting the Void if it returns and, unless Leona is nutty enough to fight Diana with hungry maws scraping against the temple gates, they are perfectly ready to do it.
Demacia and Noxus are separated by countless border states, and Noxus has recently curtailed its foreign adventures. It would have to wage a lengthy campaign of battles and sieges, only to wage another, against a fresh, well-trained, and well-equipped army, fighting on its own territory for the survival of its state. And that’s if the Demacian don’t help the border states.
The World Runes are locked in Ryze’s vault in the most secure facility on Runeterra. He’s only one left to secure.
Aurelian Sol is a danger only in the long run, if the Targonians don’t notice the degradation of his crown or, simply, set him free.
The Freljord is in a brush war, which the Winter’s Claw lacks the supplies to escalate.
Remember that Taliyah will likely fight against Xerath, if not for Azir, and seems able to confront him alone in The Climb.
Demons have been running wild for all of Runeterra’s history.
The Void is only as dangerous as it’s allowed to be. Any substatial invasion would be detected quickly, and the cooperation of Targon with regional powers would lead to a swift answer.
Karthus is a problem only if he has enough corpses and the navy to move them.
Runeterra’s doing just fine, and will continue to do just fine unless something goes horribly wrong on a cataclysmic scale.