
Yes I know these 2 are related, but not much is actually known about their relationship. I think they're friends because that's what the old lore has assigned them, but ZAC's ability previews shows ZAC fighting Twitch. Either way, both seem to be a pretty comedic duo. Twitch's insanity and craziness while ZAC has his rather calm and empathetic demanor. Not to mention that both characters honestly seem pretty lonely in general. Should have some interesting interactions.
Honestly, I'm surprised these 2 haven't happened yet. The 2 have very similar goals of wanting to make Zaun better by lowering crime, both are monstrous products of science and are now rejected by society, and both seem to lose major members of their family in the process. However, the main difference between the two seems to be how they want to do it. ZAC tries to follow his parent's morals and will only kill when necessary, thinking redemption is possible, while Warwick thinks murder is the only way to make Zaun better because criminals are just irredeemable (Despite him trying to be some form of hero, subconsciously trying to redeem himself). This seems like the perfect antagonist duo for me. Both have the same goals, but their methods conflicts drastically, yet both methods focus on the theme of redemption and morality.
This one is pretty simple in general. Both ZAC and Blitzcrank are trying to be the heroes and protagonists of Zaun in their own ways, yet their methods are pretty similar. In both stories, the two characters find danger through their unique senses: ZAC's emotion sensitivity and Blitzcrank's mechanical hearing; however, the two are drastically different. One's logical while the other is emotional. Seems like good foils to me.
Your brother sacrificed himself to let Shurima live, and look what happened to its greatest warriors...
(Yes. I'm a ZAC fan. I love ZAC)