Are the World Runes basicly Infinity Stones?
https://i.imgur.com/V7Ww9vs.png[/img] Different Colors, Check. Most powerful objects in League Lore, Check. Different effects, semi-check (?
Based on the Cinematic, there is one empty slot in the vault, suggesting there are 5 in total. In the Ryze/Brand comic, the green Rune, the woman asks if it could "Bring her son back" Ryze affirms this, tho not in the way she thinks. This would give the rune a Resurrection/Healing power, instead of total annihilation like the Red Rune seems to cause (it would seem based on the flash backs it was the run responsible for that cataclysmic explosion).
They really share a lot of themes with the Marvel Infinity Stones, including that its folly to think that the average mortal can wield them. Im not gonna critic Riot in saying that is lazy writing if its the case. Rather, id like to see what the 5 World runes can individually do, and if there is some sort of Object that can harness their power.
Also what role they will play in the future Void War. If they are ever going to be used, it should be there.