Hey Piercerson! I have been using an orbweaver because of it's extra number of keys to keybind. I use it to play quite a few games but LOL was a bit of a special one to keybind. I always have fun mapping new games. Here is my mapping for the Orbweaver.
Esc (01) | Shift (02) | 5 (03) | Y (04) | Macro [Ctrl+F] (05)
Tab (06) | W (07) | E (08) | R (09) | P (10)
Q (11) | V (12) | V (13) | D (14) | F (15)
Shift (16) | Disable (17) | Disable (18) | B (19) | Disable (20)
Thumb
Top to bottom
Alt (top button)
1, 2, 3, 4 on the four-way directional thumbpad
Space (bottom button)
Mouse
Mouse button 4 (trinket slot)
Mouse button 5 (item slot 7 [last item slot])
Esc (settings)
Shift (it's a long story why mine is there but i'd be happy to explain if you want me to)
5 (i don't put any active items in this slot but i put it right above the middle finger incase i still need it)
Y (lock and unlock screen)
Macro (to show FPS and ping)
Tab (show all players and stats in-game)
W (second champion ability)
E (Third champion ability)
R (Champion ultimate)
P (in-game shop)
Q (First champion ability)
V (caution ping)
D (First summoner spell)
F (Second summoner spell)
Shift (again long story)
Disable (don't use these keys)
B (Base recall)
Alt (Level up champion abilities, also can ping danger, retreat, caution and enemy missing)
1,2,3,4 (easy access to items without having to take fingers of champion ability buttons)
Space (if using unlocked screen, space re-centres your champion)
I main support so i always have my Sightstone or something similar on mouse button 5
But just a general assessment of playing with an Orbweaver, I just enjoy playing with it. It's easy to use once you've gotten used to it. It's great fun and allows for an easy gameplay paired with a mouse that has a couple extra buttons.