Quick idea for a mobility-countering item
(working name, but I think it's clever) Unique - Inelastic Targeting: Deal 10% of the distance the target has traveled in the last second on-hit. This excludes movement from CC.
Imagine
making his way toward you. He just moved, say, 500 units from using a Sweeping Blade and then basic MS. He's going to take 50 extra damage on the next basic attack.
A rolling
wouldn't feel it in the slightest, but squishy mobile champs would take more damage in general, especially after using high-mobility dashes
For best results, it should probably be on an item with AS and crit chance as a Zeal upgrade. Also considering making the on-hit able to critically strike. Excluding CC movement prevents exploitation by champions like Blitz, Thresh, Alistar, Tristana, etc. Teleport and similar abilities might have to be excluded as well, but I think it's a potential counter that should be considered.