Approaching Mage updates from a thematic perspective

Specifically I want to focus on . If we look at the effects poison from a scientific perspective we can identify what effects they can have on an individual.

Poison has been used for everything from murder to infertility to pleasure. Many things that are beneficial in small to moderate doses are considered toxic at high volumes(water, oxygen etc). Traditionally poisoning actually occurs when a foreign substance dilutes the bloodstream. Effects that can result can be any of the following paralysis, sluggishness, hallucinations, blindness and of course death. I think it would be an interesting for 1 of each of these effects(except for death) to be triggered as part of a (get ready for it) 3 hit passive. This would give riot a variety of tools to balance her with and allow her to be a flexible pick while maintaining her dot damage.

I know that this will be unpopular, but I'd like to start here as a discussion piece.