Champ-select mastery editing
As I was in Champ select, I was creating a new mastery page, but didnt press 'save' in time. My mastery page was complete, however, the client decided to put me in the game WITHOUT that mastery page, instantly costing me a ranked game. Try jungling without masteries and you'll see what I'm talking about... especially as a pantheon who desperately needs some early pressure to succeed (almost dying to red-buff on 1st clear really sucks).
This led to one of my most frustrating games of league ever, full-tilt-mode.
Hence I believe that when editing masteries in champ-select, your masteries should auto-save instead of simply giving you none: especially since masteries mean SO much more now than they used to.