What are your key bindings like?

I don't know what it is... but I've always found the standard moba keybindings to be a little awkward. Mostly because the keys are usually set up to be up high, and then some fast short cuts requires moving your pinky finger down a large ways while shifting your hand so you can cover your buttons.

On top of that, sometimes a few fingers might be pulled down with a few others if you don't raise them before the action.

So... I have mine set up in a typical FPS fashion.

WASD are my main ability buttons. A = Q W = W D = E S = R

R = D F = F q = Trinket Z X C V = items 1 2 3 and 5

Definitely a lot easier to press control and an ability button to level an ability up. Or to self cast an ability. Plus I can use Attack move without worrying about needing to move my entire hand back to use my spells.