Premade vs. 5 Strangers = Cancer
I think there should be a small system in the matching-up queue where premades of three or more get queue'd against another premade of three or more. [In Normals]
It's devastating to just want to practice your champion in top or mid (Or even jungle), but have to deal with a gangbang from the toxic premade on the enemy team.
From four-man coordinated CC chains mid, to behind the turret destruction in the top lane, and finally just buff trolling in the jungles.
The premade team has the advantage of greater communication, and can make better, decisive plays. While on the other hand, there are five strangers running around the map spamming pings and trying to assemble counter-ganks while one gets destroyed trying to type out a plan since pings weren't working.
However, if two premades collide then the game can be healthier, more fun to play, and not as harsh for the solo players.