Early game cheese tactics that are finally gone with new runes

Stacking full magic pen on a champion like Brand or Zyra as a support and taking ignite so the other ADC never even gets a chance to approach the minion wave without losing 80% of their HP.

Taking full AD on Pantheon and watching your Q with corrupting potion never let the enemy laner ever approach the minion wave without losing so much HP they have to back at level 2 while you laugh spamming spears.

Being able to take 24 full lethality runes and build defensive items like Maw of Malmortius, while still being able to 2 shot anything like you actually bought a lethality item.