Is everyone adapting fast to the new system's macros?
Mechanical champions like Riven, Vayne, or Draven now have slightly different numbers – basically these slight changes heavily changed macros for meticulous players. The rune changes also make it hard to know when you can cheese your opponent with low HP.
Typically, it wasn't hard to know when I would 100% cheese you if I hit level 2 right before you did as Vayne or Draven without dying. Now the new runes cause slightly more damage and less lifesteal, causing death and snowballing.
So powerspikes are also slight different. I noticed sometimes BF sword would be better than vampiric sceptre with the new mastery trees. Yes, it gives a lot of sustain but this system is more burst-oriented with our AD metas as well.
Just something I noticed.