I think the morde changes will open a lot of neat comps for bottom lane. Duo top would need a lot more organization because your jungler and mid would have to coordinate objective control and play rather passive. You would need someone like shaco to counter jungle and keep bot lane passive and someone like kat who can roam when needed.
Bot lane should have some neat comps open up with strong initiators making a kill lane possible. The exp gaps are also something to think about. For instance being level 2 when your opponents are level 1, being level 5 when they are level 3 and level 6 when they are level 4. This adds a lot of potential power for supports that don't need a lot of levels, but can aid morde in landing his damage during his power spikes.
I see a lot of scenarios opening as Morde builds shield on E, initiating with W to kill/bully the support out of lane, and then zoning the enemy carry. Once you've starved the support long enough the carry won't have anyone to protect at which point you direct you W initiations on the carry. This also forces more pressure on the jungle who has to peel a lane that is basically running at fully upgraded boots speed at level 1 . I see a lot of opening especially when you can basically ghost yourself and your teammate every 20 seconds using W.
Hybrid dps and scaling coming back into the picture also has me very happy. His best dps comes as a hybrid and with the right support he will be dueling and soloing baron with the best of them again. At the moment his ability to solo baron or duel top dueling champions (especially those using sated) has diminished. That may change.