4-Man premades are toxic to the Dynamic Queue Experience
For any solo que player, this can mean any of the foliowing:
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If they are matched against an equivalent team of 4 + 1, the better premade team will win the game. There very minimal things the solo player can do to control the pace of the game. On top of that, at higher elos where players are more coordinated and skilled, if you're playing a pivotal role like marksman and the enemy premade decides to camp your lane, you are at the mercy of your teammates. This is probably the biggest variable you will have to deal with in regards to climbing ranked alone.
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You have no control over the surrender vote. If the premade decides to surrender the game, you don't have a say in the vote.
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Bullying in general. This can refer to negative interactions in chat. The premade may try to scapegoat you (which ties into my next sentence). In champion select, the premade may disregard your role and lock in whatever they want, forcing you to fill.
Some people in the community have suggested removing 4-man premades which is a good solution. Having multiple groups of premades on 1 team is better than having a 4-man premade.