Hot key like a boss. 3 keys to success. CTRL ALT SHIFT
I'm a lefty (right hand for typing) and I am just now changing over to the number pad for most everything. THIS WAY MY THUMB IS COMFORTABLY RESTING over: •CTRL •ALT •SHIFT so I can do work.
For instance DELETE is one of my quick cast spells, but I also use CTRL + DELETE for my ranger indicator trinket, SHIFT + DELETE for my range indicator spell, and ALT + DELETE for leveling up said spell.
If you're right handed U,I,O,P would probably work. Playing on this part of the keyboard gives you so much more function. Enjoy!