@Riot will the new Rune system include penetration options and other more niche runes?

sometimes I run 24 Lethality or 20 magic pen on characters. I feel like this extra penetrations are needed to give my builds the extra "push" that makes them perform adequately (it usually gives enough armor pen to give true damage against most marksmen and mages). I would like to know if things like full armor pen will still have similar options available to them.

or will the new Rune system still keep more niche and cliched options like Energy Regeneration or Mana regen per level? I actually enjoy using certain runes to enhance certain characters (like running 36 mana regen @ level 18 on or full Energy regen and 45% CDR on 62 armor @ level 18 on 52 AD @ level 18 on and ) .

I would really hate if said stat manipulation options were removed completely. I guess what im saying is ? in the great transition will base stat manipulation still exist? Can more "fun" and non meta playstyles remain intact?