The problem with the majority of runes...
Is that damage is too reliable. If we want any of the runes to have any meaningful purpose or the majority of the runes I should say that aren't damaged oriented we have to shift Focus From the fact that right now killing everything as fast as possible is the most efficient way to win games.
I'm not going to go in-depth with this because I don't have the time but what I'm basically saying is all the runes that have specific uses are really cool but will never be used just due to the fact that they are negligible versus the other damage oriented runes. Literally almost everyone in the secondary tree is running Triumph and Coupe de gras, literally everyone that I see just because of the damage Factor.
There's really cool runes to use like in the inspiration tree, slightly magical boots, perfect timing, and they are good those specifically, but as it stands for the majority of Champions damage is just too strong and too reliable of a stat to give up on for these other non damage oriented runes. If Riot wants to balance a MOBA between Champion control and objective taking, damaged needs to either be tone down or a lot more Focus and reward needs to be put into objective taking, not just gold. Strategic gameplay is lacking is basically what I'm getting at, and it's sad to see. I hope something in the future changes hopefully soon