Ahem, True damage, as annoying as it is, is not really as big of a deal as you make it out to be. Fristly, let me say first that Spell Vamp was already removed apart from some champions having it back when they pulled Will of the Ancients. And as with Yi and red buff. Crest of Cinders deals 4 - 38 (based on level) bonus true damage three times (from the wiki). In total, that's about 127 damage to one person. Not sure if there's a reset or a stack, but there you go.
Blade of the Ruined King does not do True damage, it does
UNIQUE Passive: Basic attacks deal 6% of the target's current Health in bonus physical damage (max 60 vs. monsters and minions) on hit. Life Steal applies >to this damage.
UNIQUE Active: Deals 10% of target champion's maximum Health (min. 100) as physical damage, heals for the same amount, and steals 25% of the target's >Movement Speed for 3 seconds (90 second cooldown).
AKA, can be blocked with straight Armor.
Vayne might be considered high if it weren't for the fact she has short range and is better suited for being a Tank Melter.
Every third consecutive attack or ability against an enemy deals an additional 6/7.5/9/10.5/12% of the enemy's maximum Health as true damage.Deals a >maximum of 200 damage vs. Monsters and a minimum of 40/60/80/100/120 damage vs. all targets.
If you're building health, yes you are going to have a bad time in trying to fight her so it's better that an APC can pop her before she manages to get autos off.
Darius is another oddball in the fact that yes, while he does a lot of True Damage, he does fairly little if he doesn't get Hemorrhage stacks off and is more suited to killing ADCs and APCS.
Leaps to target enemy champion and strikes a lethal blow, dealing 100/200/300 (+75% bonus Attack Damage) true damage. For each stack of Hemorrhage >on the target, Noxian Guillotine deals an additional 20% damage.
Maximum Damage: 100/200/300If Noxian Guillotine kills the target, it may be re-cast at no cost within 20 seconds.At rank 3, Noxian Guillotine unlocks - its >cooldown resets entirely on kills and it no longer has a Mana cost.
Tanks and heavy CC can keep Darius down as he needs to be fairly close to his target to get it off. Which means why aren't you peeling for the carry and allowing him to get his stacks off in the first place?
Garen, however, does do a lot of true damage which is pretty much his entire kit. As soon as his ult goes on CD, he's just a Beyblade with no other real purpose so building a GA is great if you're very squishy.
The enemy champion with the most recent kills is the Villain. Garen's attacks deal additional true damage to that champion.
Garen can call upon the might of Demacia to deal a finishing blow to an enemy champion that deals damage based upon how much health his target has >missing. This damage is true damage against the Villain.
Passive: The enemy champion with the most recent kills is the Villain. Judgment and basic attacks against it deal an additional 1% of its maximum health as >true damage.
Active: Garen calls upon the might of Demacia to attempt to execute an enemy champion, dealing magic damage equal to 175/350/525 plus 28/33/40% of >the target's missing health. Deals true damage to the Villain.
Again, CC and tanks who aren't marked can at the very least hold them at bay while someone just builds Armor Penetration and ruin him.
Btw, didn't hear you complain about 
who's Q deals 40/65/90/115/140 (+35% Ability Power) magic damage on the way out, and 40/65/90/115/140 (+35% Ability Power) true damage on the way back.Ahri gains movement speed that decays while her orb is traveling. Keep in mind that it's on a roughly 4 second Cooldown, so basically she can do about 500-600 True damage late game.
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