Enormous balance changes, making many marksmen more different from each other, all having largely defined roles. Also fully reworking the early game and gold.
Completely new champion select, making ban order make more sense, giving everyone a role before they join, and giving everyone the ability to show what they want to play to avoid bans to that champion.
Getting kicked out of promos, then climbing back up, gives you a free win.
Matchmaking is better for high elo, making those streams less unbearable to watch.
You can get tons of crap for free by doing well in games, and through random chance.
You can set up "clubs" to keep your large groups together (for fan-made game modes, IRL groups, etc.)
Parties don't disband post-game.
There's an app to talk to people with.
NO MORE ADOBE AIR CLIENT
Oh yeah, there's a thing where you can go into Ranked with anywhere from 1-5 people. I guess that's a bit odd- HOLY SHIT WHY IS EVERYONE FOCUSING ON THIS