Possible Life Form Disintegration Ray bug
It seems that sometimes when firing Life Form Disintegration Ray immediately following a combo of other abilities, it will fire off in some other direction, completely missing. I may be jerking the mouse in a tense moment, or there may be some sort of lag issue, but I feel like it happens often enough (once every few games, and only immediately following a rapid succession of other ability uses) that it's at least worth exploring, especially given the bug a couple patches back about cone spells doing something very similar following combos.